Perhaps I can be of assistance, as I have one of the huge ASM Colt Walker revolvers (circa 1970's) that I have 'shot loose', and it is displaying signs of high pressure(s). I accomplished this stupid act approx 15 years or so ago by repeatedly shooting the revolver with full chambers of Pyrodex 'P' powder. ((The resulting cannon 'boom' is a sight to behold (and hold!) however...so I have no regrets on that regard.))
1) The cylinder pin has a noticeable wobble when the barrel and cylinder are removed. (very evident)
2) The barrel wedge is getting a noticeable depression on the cylinder facing side. (slightly evident)
3) The barrel wedge slot (on the barrel) is deforming on the cylinder facing side. (very evident)
4) The barrel/frame mating point now has about a 1/16" of 'slop' or 'play' in it. (very evident)
5) And for the Walker revolvers, the easiet way to tell that the revolver is 'overcharged' with powder is that the loading lever drops down from the recoil when the pistol is fired.
(This Walker never did ever 'cock itself' from recoil, no matter how much powder was stuffed into it.)
I don't remember what the exact weight of the charge was, as it was so long ago, but I seem to remember it being in the upper 40's grains range...approaching 50 grains of powder or so.
I wouldn't hesitate to shoot this revolver again, as there is no fear of the cylinder exploding or anything like that...I just wouldn't shoot it with any more than 30 grains or so of Pyrodex for fear of damaging it any further. Pretty strong revolver, actually ...the original 'Magnum'. If you get a chance to lay your hands on one at a decent price, I would suggest you buy it. You won't regret it. Just to look at and hold one of these massive pieces of history is worth the price, IMHO
(By the way, the load was a .451 round ball with the chambers plugged with CVA grease patch.)