Got my first plastic container of IMR Trail Boss Powder and tried some in two .45 Colt revolvers and a .45 Colt rifle. Testing was done at short range into a plain dirt bank. Accuracy above a general impression was not assessed, due to a lack of facilities. The stuff looks like a bottle full of teeny Cheerios and is very bulky.
My first trial was with Starline cases, Winchester standard primers, and Meister 200 grain bullets sized .454 inch. The first load tried was the listed minimum (5.5 grains) from data take from the IMR website. This light load shot like a dream in a Cimarron SAA with a 5&1/2 inch barrel and in a Ruger Original Vaquero with a 4&5/8" barrel. Like most light .45 Colt loads, it did not seal the breech well, but made up for that by burning cleanly, leaving essentially no unburnt powder and only light amounts of powder residue--even with this, the lightest load. This same load in a 1873 Uberti/Cimarron Winchester replica did not seal the breech well, either, and light amounts of gas from the breech could be felt as a round was fired.
Heavier loads to follow tomorrow. There is only one grain of powder difference between the lightest recommended load and the heaviest recommended load.
The only real problem encountered is that of metering in my measures. The 5.5 grain powder charge filled about half of a .45 Colt case and took up most of the available metering capacity of my Redding measure with the pistol metering chamber. I could not get the Redding to meter the maximum load, 6.5 grains, with the small chamber. About 1 out of 6 charges would be unacceptably light when thrown with the Redding, some by quite a bit. Perhaps that indicates bridging in the measure. When I switched to a Harrell measure, measuring was very erratic, and I eventually gave up and went back to the Redding, but with the larger rifle metering chamber installed. The Redding measure with the larger chamber would maintain about +/- one graduation on the end of the beam from charge to charge. Tapping the powder measure at seemingly appropriate times during measuring did not seem to improve the uniformity of the throws. I am going to guess that this powder, which is essentially a flake powder with a central hole, will be like metering shotgun flake powders. Perhaps the constant mechanical jiggling of a progressive press, like that of a shotgun progressive machine, will help even out the powder measuring situation.
General impression: decent stuff, but weigh charges until you can prove that your mechanical metering methods are sound. The sealing of the breech in .45 Colt rifles is characteristic of the fifles, not the powder. I have tried at least 8 or 9 powders trying to solve that problem and so far Holy Black is the best solution.