I also shoot full-power black powder loads. When I shot smokeyless, they were also always full-power. My non Ruger guns have held up just fine after tens of thousands of rounds. Needless to say, my Rugers have held up fine as well. After 13 years of shooting my AWA Longhorn (45 Colt) I broke a spring a couple weeks ago (during maintenance, not at a shoot). I consider that normal wear & tear, not a failure.
Matter of fact, the ONLY catastrophic failure I've ever had (of a cartridge gun) was while I was in the Army, when a firing pin broke in my Remington-Rand 1911A1 during a pre-combat inspection, while performing the Manual-At-Arms for my Commander! Luckily, he knew how much of a stickler for maintenance I was (which was why he made me his Armorer and go-to guy for small arms - before I went to Master Gunner school) and we both got a laugh out of it. I'd still love to know how many times that firing pin had been hit by the hammer before it broke, since the last of the Remington-Rand pistols were made during WWII.
Just a note ... when I say full-power, I don't mean OVER spec loads like some think "warthog" means. Having shot with C.O. Jones, I know that is also what he means.