My Chiappa .56-.50 Spencer barrel came loose at a match. I made a conscious effort to hold clockwise pressure on it for the remaining stages. When I got home, I took it off, degreased both sets of threads, applied blue Loctite, and screwed it back in as tight as I could with hand pressure. I let the Loctite set up good for about a month, and started shooting it again. That was probably at least eight years ago, and it's held fine.