I am not saying you'll have any problems going to the lighter bullets...BUT...if you reduce the bullet weight and want those low velocities, you are going to go to a faster-burning powder to get decent ignition. But, faster-burning powders will take up much less space in the already "cavernous" .45 LC cases. You may be fine, but as the powder moves around in the large volume of space, you may get some larger variations in muzzle velocity. Trail Boss is supposed to reduce the problem. However, I have found that Trail Boss works best with loads in the mid-range of the published data. Also, with ALL smokeless powders, and regardless of bullet weight, I strongly recommend a firm roll crimp on the case mouth. How firm? Enough that you can see the curvature, but NOT so much as to bulge the case wall away from the bullet's side.