Sixgunner 1965,
Unfortunately, there is no definitive answer to your question. Essentially, you shoot it until it splits and then toss in the recycle box. The
life of the brass is dependent on the alloy used, the stresses during drawing, the heat generated when firing and even more important,
the amount your chambers are out of spec.
Uberti large bore rifles are notorious for "Generous" chambers. VERY Generous. With 45 Colt, there is always going to be an amount
of Blow-By. It's the nature of the cartridge. It simply does not expand (in factory form) to gas seal the chamber. Period.
Using the old "stand-by" of loading a heavy powder charge behind a heavy bullet only serves to shorten the case life. It is not a wise
choice. I have suggested in the past to use 44-40 cases in 45 Colt. It comes from the manufacturer with a nice thin case mouth and
no taper. It will expand quite well. Not perfect, but quite well. Big heavy bullets and heavy loads are not required with 44-40 cases.
Annealing is a good choice too. Again, big heavy bullets and heavy powder charges are not required with properly annealed cases.
My additional suggestion is once the case has been shot with heavy-heavy, do NOT full length resize it. It is now partially fire-formed to your chamber. Nick size the depth of your bullet only. The less you "work" the brass, the longer it will last.
Coffinmaker