I've held off commenting because I know that there are those with more experience than me, but it seems that my experiences might assist here.
I started loading the .45-70 in 2005 when I bought a Miroku 1886 rifle. I had Reloder 7 on hand and I knew that it was one of the recommended powders for that cartridge. That gun has a rather strong action, so I felt that I could go above the loads recommended for the 1873 Springfield rifles. I started with Remington jacketed bullets, but switched to lead when I started casting in 2008. I haven't fired a jacket bullet in that caliber since. I started with Lee molds in their 405 grain hollow base and 500 grain pointed versions (single loading the pointed bullets in my 1886). I later purchased a Lyman 457193 mold when I damaged my 405 grain Lee mold.
In both cast and jacketed bullets, Reloder 7 has worked really well for me. I was able to step up the velocity to over 1600 fps in my 1886 rifle with no issues and great accuracy. I also have slowed it down for some practice rounds, although I kind of like the sore shoulder and bruising that comes with full charges.
Last year, I bought a Pedersoli Sharps through Gunbroker, and I really enjoy shooting it. Mine has the 32 inch barrel. My 1886 has gotten a lot less use since I got the Sharps. I use bullets from both of my molds with it. If I step up the velocity too much in the 500 grain mold, the bullets tend to keyhole. I also backed off the powder charges from what I use in my 1886 to keep the pressures down a bit. For lighter loads, I use 35 grains, which with the 405 grain bullet (which is closer to 415 with my alloy) gives me 1360 fps. That’s pretty close to BP velocities, so that is kind of a standard load for me. If I push it up a bit, the velocity is closer to 1500 fps.
I've used IMR 3031 with this cartridge too, and it works fine, but I've bought my Reloder 7 in 8 pound kegs, so I tend to save my smaller quantities of 3031 for other cartridges.
I'd be
very careful about using relatively fast burning powders like Unique in the large .45-70 case. It can be done safely, but I feel that there are better choices. I haven't used it, but 5744 is also a popular choice.
Those are my experiences. I love shooting both my 1886 and Sharps rifles and I've found it a great cartridge to handload and cast bullets for. I know you'll have fun with your new gun!
CC Griff