Yes, blackpowder (and subs) will have a deeper "boom" report, while smokeless loads tend to "crack". I don't much like the subs, because they are more corrosive than true blackpowder. But the real stuff is harder to come by; most LGS's don't stock it due to the storage requirements. I wonder about that 22 grain load being high enough, though. I don't know how bulky cleanshot/Pioneer powder is compared to blackpowder, but you don't want any airspace between powder and bullet with either blackpowder or the subs. Supposedly, dangerous pressure spikes can occur in this situation and wreck the firearms. 22 grains is far from a full load; it may not be full enough. But as long as there is no airspace, then I wouldn't hesitate to shoot it in your Schofield replica. I routinely shoot a compressed load of 40 grains FFF Goex under a 255 grain bullet. Recoil is high--as is velocity (over 1,000 fps usually), but pressures are lower than with any comparable-performing smokeless load.