Howdy Again
I shoot nothing but .452 bullets in CAS. Both the PRS 250 grain Big Lube and the J/P 45-200, invented by a couple of guys named Johnson and Peterson. I can shoot them all day long in my 2nd Gen Colts, even though their chambers are a little bit oversized like many 2nd Gen Colts. Doesn't matter. With plenty of SPG in those bullets, I can shoot my Colts, or my Rugers, or my clones all day long without any binding at all and without any cleanup at all. Blowby is not an issue.
My 1858 Remmies with their R%D conversion cylinders are another matter. They bind up quickly. However it has nothing to do with bullet diameter or blowby, it is because the 1858 Remmie lacks a cylinder bushing to deflect fouling blasted out of the barrel/cylinder gap away from the face of the cylinder and the base pin. They bind up after just two cylinders full. However, like I say, it has absolutely nothing to do with the bullet diameter, design, or blowby. It is a design flaw in the 1858 Remmie.
Blowby will only be an issue with fouling binding up the rear of the cylinder. If you are getting binding at the front of the cylinder or the cylinder pin, blowby is not causing it. Blowby is by definition powder gasses sneaking around the case towards the rear. Has nothing to do with fouling in front of the cylinder.
As I said earlier, the real purpose for .454 bullets is for older revolvers with .454 diameter barrel grooves. Revolvers made since 1956 have .451 diameter barrel grooves. If the cylinder throats are near to .451 or .452, a .452 bullet will work just fine. If you have oversized chamber throats, the .454 diameter bullet is a good option.