I use a spare bedroom upstairs as my 'Gun Room'. Safes are in the closet, reloading and cleaning is done at a Craftsman workbench with drawers on one side for cleaning equipment, wads, belts/holsters, gunsmithing tools; the other side has shelves for storage of brass & bullets, and 2" high drawers to hold some of the C&B revolvers. On the wall there are a couple 36" wide wall cabinets. One holds reloading dies, primers, manuals, and other supplies, other holds books, C&B supplies (caps, flasks, balls, etc), and some old 12 ga reloading tools.
Reloading presses are mountes on 2x12s so they can be C-clamped to the workbench top when needed. Have a Hornady L-N-L; RCBS Rock Chucker; 2 MEC shotgun loaders; and A Lee Loader II 12 GA press mounted that way. When not in use, they're stored on top of a bookcase, or in the closet out of the way.
Had vinyl flooring put down when house was bulit so it would be easy to keep cleen. On one wall is a hat/coat rack that I use to hang gun belts, holsters, spurs, hats and other CAS items.
Also have a desk and a couple bookcase to hold magazines, books, and papers.