Another thought here also centers around WHERE your bullet design "likes" to be seated.
It could turn out that in order for your bullet to be seated out far enough to be close to touching the rifling, it may expose one or more Grease Grooves?
In the case of competition BPCR shooters this is what they may do. It allows them to get as MUCH powder into their cases as possible.
However, from a practical "field" standpoint, this may not be a good thing to copy.
You're not going to want to be using cartridges loaded so that the grease can either be rubbed out of the grease grooves nor allowed to collect dirt or grime, so your grease grooves want to be INSIDE the case walls.
As you know, changing the relative position of the bullet to the chamber's Leade may affect accuracy.
Where the exact setting is "best" has to be determined by trial and error.
And I'd go further and say this.
If you don't have a relatively powerful scope mounted on your rifle (and most BPCR shooters don't), and I'm saying something in the 15X to 20X range, you're really not going to know all that well.
Iron sights, are "sufficient" for good "Buffalo" (even large Match sized centers) accuracy.
But they're not really going to tell you that much about "tack driving" accuracy while working on loads and bullet settings etc.
For an example I cite a couple of my varmint shooting rifles. One, a .223, can shoot "dime sized" groups all day long. It does this with the aid of a 16X scope I have mounted on the rifle. At 100 yards, I can see the bullet holes as they get punched into the target. I can aim on the hole I just shot, if I want (but usually find more consistency if I aim at a sighting point ala Bench Rest style).
So what I'm saying is if you're using your Iron Sights, especially your Rear Barrel Sight, you're going to see ~2 MOA accuracy, best case! (I know, others will argue this with me, but I contend that "conditions", lighting, your eyes, your ability to "see" things exactly the same over different days, and "line up" your sights EXACTLY the same shot after shot using Iron Sights is going to vary. You'll have days you shoot better and others, worse. And it won't have anything to do with the rifle itself!)
So, while ppl here can make recommendations of things to try, maybe where to start, only you trying this, by trial and error, are really going to figure it out.
I also guess I'm asking HOW accurate do you anticipate you need to be?
I think I'd try just loading up some rounds and getting out there and shooting your rifle and seeing how you/it shoot.
Then, if you think it needs some improvement, you can start from that baseline and work on improvement.
I really don't think you can pre-plan (best) accuracy out in advance.