With a 45-60, if you can hit where you want to, you can kill it. The trick is to hit it where you want to. The rainbow trajectory is your enemy. My solution is a folding leaf open sight zeroed for 50 yds., and a tang sight set for 100 yds. Depending on the country, you can sight in the at the best ranges for your need with the two sights. After that, it's practice, practice, and more practice.