Check the extractor for burrs and also for fouling or dirt under it. Ejecting fired cases can drop unburned powder or fouling onto the cylinder face under the extractor and close the headspace up. Always clean under the extractor when you are cleaning the revolver. (This is also a concern when cleaning modern S&W and Colt double action revolvers)
Yes, the cylinder should spin free, which brought up my extractor cleaning comment. Also see that there is a hair of endshake, (up to .002) enough that the cylinder doesn't bind, and look for burrs or damage to the front edge of the gas ring of the cylinder. Make sure the cylinder is not dragging on the frame or topstrap anywhere, sometimes at the rear edge, depending on the latch position.
An improperly adjusted latch can cause problems. When reassembling the Barrel Block you swung up to release the cylinder, after removing/cleaning/replacing the cylinder, leave the two Barrel Block (catch) screws on the topstrap a bit loose until you have closed the action, to let the Barrel Block on the topstrap seat itself fully into the dog on the frame mounted Stud Latch (rear sightl/latch), then with the gun snapped closed, tighten the two screws