Howdy Kid. As long as the OAL is kept under 1.600" the ammo will feed. Measure the carrier opening in the bottom of the frame. This measurement is your max OAL. There is a lower limit as well around 1.4 or so, but you don't have to worry about that with 45 Colt. Bullet shape will affect chambering. Generally, avoid semiwadcutters or anything with a sharp shoulder. RNFP or TC are good. There are very common 200gr RNFP bullets sold by bullet makers that are the exact same OAL as the 250gr, just less bullet inside the case. Be sure you have a flat nose, larger than a primer. Anything that will fit and feed in the Henry will chamber in a handgun. You probably know about the rules for safely loading the magazine, right?