Been several weeks since I commented on this thread but I have been setting up a loading machine, researching loads with 2400 in the 45 Colt and then loading small batches for testing. I finally found a day when my decrepit bad back seemed willing to let me venture out on the range with all the paraphernalia necessary to do some chronographing. The results were disappointing but educational.
I tested 4 loads of 2400: 15g; 15.5g; 16g and 16.5g all behind a Berry's 250g bullet. I initially shot them from a 4-3/4" USFA through the Skycreens of my old Oehler Model 33, set 10 ft. from the muzzle.
15g averaged 790 fps, with an Extreme Spread of 66 and Standard Deviation of 29. Not bad but not quite where I wanted to be. I was hopeful about the next load of 15.5g.
It delivered an average of 881 fps, a little hot from that barrel length, and was quite inconsistent. ES was 118 and Sd was 49. Since I was there I tried the next load of 16g, expecting it to be even hotter.
It wasn't with an average of 879 fps, and ES of 136 and Sd of 51. These are getting worse, i.e. more inconsistent.
And finally 16.5g, which as expected was too hot for my purposes, but was a more consistent load than the previous two, averaging 933 fps with ES of 64 and Sd of 28.
If I just wanted a 1000 fps 45 Colt load with 250-260g bullets for something like a Ruger I would be all over further load development with 2400. But, since my goal was to duplicate black powder performance as closely as possible with a smokeless powder I'm going to have to look elsewhere.
Dave