I have had several Vaqueros in the past few years. The 1st was a 45 colt with 7.5" barrel, later added a 4 5/8 version. Sold those to go with a 44 M to go with the 44 carbine I had. Hard times hit, so I had to part with all before I got a chance to replace the 45's with the 44's. Later got the 44's, but had trouble with my wrist, and didn't like the 3-4 day after-effects of the recoil shooting full-house BP loads (don't like downloading, just my quirk). I now enjoy a 5.5" SS 357M original Vaquero with black micarta grips, and use it along side my 36 C&B's, when I am not shooting frontiersman, and 1894C Marlin carbine.
I have no regrets. BTW...I save about 40% in powder and about the same in lead costs, which helps out on my always-tight budget!