HoKay Deacon
Based on some of yer own comments, electing 45 Colt would be a mistake. The larger straight walled pistol cartridges WILL NOT obturate (expand) to seal the chamber under normal circumstances. You WILL get Blow-By and it can get nasty. With 45 Colt, especially Uberti with their "generous" chambers, you only have two choices for true happiness. First up, Anneal your cases. You said you don't want or intend to do that so go ahead and shoot yerself inna foot. Next up is to fire form 44-40 cases to 45 Colt. The thinner case mouth of the 44-40 case will seal the chamber nicely. The cases will look some wonky at first firing but don't worry about that. You do have to run a 45 expander die CAREFULLY thru the 44-40 case.
As an aside: there are those who recommend a real BIG bullet and a real HEAVY load to fix the Blow-By of the 45 Colt. Hog Wash. That practice may mitigate it a bit but won't do anything but waste lead and powder and still leave ya with Blow-By. Annealing and 44-40 cases are the only two effective solutions.
Next up is .38. I'm not gonna say anything. Just scroll back up and re-read MAKO's stuff. Says it all and more eloquently than I. Just pay attention to cartridge OAL in ANY '92. And . . Get Steve Young's DVD and spring kit for the '92.