My Good Rio
As our friend Coffin relates, it might....
I will revert to my trademarked advice: "It Depends" ™
A lot depends on the age of the gun, the part, and the model.
I have literally swapped in an Uberti SAA hammer assembly into both a Pietta and ASM
1851 and 1860 frame with easypeasy success. You would not believe how smooth the thing was after!
I have also been totally unsuccessful with other frames and supposedly identical parts, just based on year of manufacture.
I am currently ( verrrrry slooooowly) grinding away at several parts (and filing the internal hammer channel in the frame) to make a frankenremington out of an unknown very old smaller frame I got very very very cheap. If I had started out smarter, I would have left the frame alone and just kept thining all the parts. But noooooooo I thought (always dangerous) that I would "fix the frame" so I could always use newer parts...
So, what is the make, model and year ? That can help determine ...
If it is late model and a cartridge pistole , your odds improve....