I would expect that any original .56-46 Spencer ammo would (a) not fire; and (b) would be collector's items, and priced accordingly, so you would be shooting up a bunch of money. I'm not sure if a Spencer sporting rifle would accept a centerfire conversion breechblock or not. You'd have to measure the inside receiver and breechblock dimensions and check with S&S Firearms to see if their centerfire blocks would fit. (Even on the standard military rifles and carbines, the centerfire blocks can require some fitting.) If that hurtle is jumped successfully, you will then be faced with making reloadable brass, which for the .56-46 might be a bit more work than with the .56-56 or .56-50. Frankly, I'm not sure of the actual groove diameter of the sporting rifles...possibly a .44 or .45. Might want to slug the barrel to see what's feasible.