Uncle Eph,
I have not had this done. I have talked with the folks at Traditional Effects and my favorite gunsmith. It should be possible. The cylinder is the same size as a the ones on my Model Ps. What got us thinking about it is Uberti catalogs the Opentop in 45LC for Europe, but it has never been imported before. It is the same gun, but none have made their way here.. so it's just guess work.
I would suggest that anyone looking at this work have a very competent gunsmith look over the gun and do the work.
Adios,