Froogal
45 Colt "what"
Pistol?? Rifle?? 1911?? 10 Pounder field Piece??
So, with Black Powder you're gonna get fouling to some extent regardless. Black Powder fouling is cumulative. Builds up a little every shot. Doesn't matter what cartridge you use. It does matter the "quality" of yer powder. The other prime consideration is to keep the fouling soft. Hence, we like lotza lube.
Cartridges: 45 Colt and other straight wall cartridges will foul the chamber and in many cases the action from "Blow-By" of gun gasses. Icky Foo, unless precautions are taken. Blow-By can be eliminated by annealing cases. You can also eliminate blow-by in 45 Colt by fire forming 44-40 cases to 45s. Unfortunately, there is no other case choice for the other straight wall cases. Anneal them.
Annealed cases will not affect the fouling lift in the bore. Only keeps the chamber and the action components clean, free running and sanitary.
Last Choice. Switch. Switch to APP. APP requires no lube and the bore fouling is not cumulative. Each shot cleans out the previous. APP can and will foul the chamber and action though, if enough Blow-By is present. Annealing and or 44-40 fire form'd will probably be required.