In Maj. Geo. Nonte's book MODERN HANDLOADING he writes:
45-75 Win. 350gr bullet no. 457192 , 22gr of 2400 powder.
50-95 Win. , 300gr bullet no. 515139 , 24gr of 2400 powder.
50-110 Win. 330gr buulet no. 515139, 52gr of 3031 powder.
50-110 Win. 450gr bullet no. 512138, 50gr of 3031 powder.
2400 can be very accurate. My experience in the
45-70 Gov't required a tuft of poly fiber fill with 23 gr of 2400 powder,330gr bullet, otherwise it was a incomplete burn with lots of unburned powder. I wouldn't use any other filler.Poly fiber fill/kapok vaporizes instantly and gives you expansion room.
NOTE: You will have to experiment and work up to your loads.
You're responsible for your own hide with the info.