Well Schucks
I hadn't thought everything through (sometimes I don't think at all
). I shoot a bunch of different Uberti 45 Colt brass rifles. Henrys and '66s, and a 44 Special/Russian Trapper. I don't shoot big 'Ol heavy bullets in any of them. In the 45s, the heaviest bullet I shoot is a 200Gr RNFP. Heaviest bullet in the 44 Trapper is 165Gr RNFP.
While I use to shoot that Heathen Fad smokeless stuff, I have seen the light and now shoot smoky stuff. It has made NO difference the propellent. ALL of my Uberti Brass guns shoot pretty much to point of aim with the lighter bullets. Even 160Gr .45 flying ashtrays.
I would not go chopping and channeling your sights until you piddle with different bullets. Trying to shoot "whatcha got" is not so Bueno. Often you will have to find what the rifle likes. Kind of like trying to feed Broccoli to a three year old