Actually the results are not yet all that conclusive, but I just want to relate a bit.
I loaded 10 .45 Colt shells with 30 grains of the FFF, and another 10 with 25 grains and one .7cc dipper of cream of wheat. 200 grain lead round nose, flat point bullet. Cimarron 5 1/2" barrel.
Shot the reduced loads first with no issues. Ejected those spent rounds and then loaded up the full, 30 grain loads. Again, no issues, and not much difference in noise, but when I tried to eject them, I could get only one, and the cylinder locked up. I pulled the base pin and the cylinder came out with just a little persuasion, but the base pin bushing required even more persuasion to remove from the cylinder.
I have more to learn, but for now, I think I will stick with 25 grains and cream of wheat.