Elk antler is so porus it is quite a challenge . I make knife handles from deer and stag antler and made some grips for a rem 1858 from stag. They were small enough and thin enough as two slabs to be similar to knife handles.
I have never done anything as big as a one piece SAA grip or a S&W N frame target grip. My bigest knife handle grips were all blind stick tang drilled into the antler so movement has not been an issue.
I have heard that some folks “heat and flatten” in order to get a large piece. But Once you cut a slab from an antler you open yourself up to movement.
A lot of folks make a rough slan then stabalize it with a lot of superglue, resin or epoxy. There is a new one ingrediant expoxy that is cured by UV lamps, this holds some interesting promise since you can give it time to soak in before curing it.
When i cut, sand or polish any horn or antler I use bentilation (it stinks) and ALWAYS wear a quality respirator like this
https://www.lowes.com/pd/3M-Reusable-Sanding-Valved-Safety-Mask/1000244145An N-95 mask is not enough.
I usually polish on an 8 inch cloth wheel on a grinder, using red rouge and mild pressure. You can burn the antler so be carefull.
Oh, and if you work it after stabalizing, the glue will emit vapors also.
Hope this helps
Prof marvel