I tried the Ruger and the feel of it in my hand made me sell it before I had ever fired it. Mind you, this is a subjective reason, nothing to do with performance of the piece.
I went with the Beretta Stampede, as the grip is much more in line with a Colt. I have had none of the problems wiht them that several people have reported, and as a "non-prototypical" old west gun (due to the transfer bar safety), it still looks like a Colt on the outside.
I next purchased a USFA Rodeo, and with that purchase I discovered the quality and good looks that an American made gun offers. Because the quality of real Colts has suffered in the past, it makes it a tough decision what to go for as a "long-term" "top-of-the-line" pistol. My personal decision will be to go with USFA, either Rodeo's or SAA's or ...
My advice is before you even fire one: try handling several different kinds, Rugers, Italian clones, American clones. If it is not comfortable in your hand, no matter how good a gun it is, it will never be good for you.