I hang out at the opposite end of the spectrum. Anointed, Card Carrying, Self Proclaimed, Dedicated, No Doubts Recoil WIMP!! I would find 35Gr with a 255 to be just a mite stout. I would personally think, shooting that heavy more than once "just for the fun" to be some silly. However, that's personal. Those that choose to shoot "bigguns" are more than welcome. HOWEVER:
The 45Colt cartridge concept is super flexible. Full 45Colt case, tone of gonne powder .. BOOM!! 45 Schofield case, some less propellent, lighter bullet, less BOOM. Cowboy 45 Special case, way less propellent, itty bitty bullet, gobs of FUN .... less Boomb.
I have several sets of Colt Pattern Cap Guns set up for conversion cylinders of .45 persuasion. I shoot C45S cases, 150 or 160Gr projectiles and 2f in all of em. Very pleasant to play with. Although I still have some 45 Barnstormers carefully husbanded. 130Gr, hollow base wad cutters. Really FUN!! NO!! I won't share the Barnstormers. Nowhere to get more (sniff sniff).