Ah Heck. This one Stumps me. Normally I wouldn't stick my toe inna water without something positive to add, or nasty, if it's a Monday. But, I don't honestly know the answer.
There is the worn out answer. You can do anything with enough folding money to throw at it. Personally, were it mine and I needed to chase "everything," I'd stick with the small caliber. Everybody has 38-40s and 44-40s. 25-20 not so much.
Coffinmaker