I've been loading 50-70 for my Shiloh carbine and Military Rifle for years using Mike Venturino's recipe.
Lyman 515141 (sized .510) over 65 grs of FFg. No wad. No compression other than from the bullet. Venturino said that when he first started loading 50-70, he had no .50 wads on hand, so he didn't use any. Results indicated they were unnecessary.
For a little less recoil I use the same powder charge with a 375 gr Rapine bullet.
With the Lyman bullet in the carbine, I hit 28 oz. tomato cans at 100m off hand. The same load in the MR has dropped two 400+ lb black bears and a 6 pt Mule Deer.
I suggest a read of Croft Barker's book on reloading the 50-70. He covers all the bases.