Thank you guys for your replies. I was asking whether the 45-60 had EVER been used, not particularly as a primary weapon. I was just curious to know whether it was indeed possible. I don't intend to shoot a buf but I was wondering if it were even an example in the "old days". I am an old codger, and grew up going to a wildlife refuge in Southern Oklahoma, where buffalo abound, and it always seemed to me that a 300 grain bullet from 45-60 would be iffy, at best, but like Buck said in his post, it was the worst of the lot. Thanks again for the knowledgeable replies.