This is indeed a touchy subject, the use of fillers. I have posted of my load development for the .45-75 using puff-lon on the forum. Been loading almost 40 years and this is the first I have used a filler. I am not wild about the idea but after reading on getting reliable ignition, and velocity consistency in the big case using 5744, decided to try a filler. I didn't and still don't feel comfortable using kapok, Dacron or other materials and if not for puff-lon would most likely not use it and just try to go with the issues I have read of with ignition problems and such. Did a good bit of reading on the puff-lon product and decided to try it. This is at least produced specifically for being a filler. So far so good, but I am still not fully at ease using it. The 45-75 is the only cartridge I use the puff-lon in. Lot of typing to say, even though I am using it the jury is still out with me. On my wish list for working with the loads is trying no fillers and some other powders. I am no stranger to loading for a bigger case, the .375H&H ain't exactly small and I have never felt the need for a filler with that rifle, course it is not based originally on a black power charge either. This is a sorry reply as I reckon I am still trying to decide for myself, but I can report that so far I haven't experienced any problems with puff-lon, seems to do as advertised, just wish I knew more about what was going on in that case when you touch it off. Best of luck with it and keep us posted on how things go.