Well, if you gotta you gotta, but I'm not sure I'd drill 'em out to the 45 Colt. True, the 45 Schofield ammo is $$$ . As I say, "whatever cocks your pistol". Yep, I'm bitten, smitten, whatever by the OTs but have steadied my wants so far. I just traded for an 1866 w/24+" octagonal barrel and DOES it ever shoot !! Oh, it's 45 Colt but does handle the Schofield ammo just fine.