I have seen about maybe 25% of the "New" Vaquero shooters come across the loading table with this mod done.
Seems to work fine as far as I can see. I don't shoot any "New" Vaqueros, so I ain't tried it.
For those of you who
load 1, skip 1, load 4 (ala Colt) you really don't
have to do that.

You can actually spin the cylinder (in correct rotation) once loaded to see if you have a high primer.
We always do it & no one has ever said a thing about it. Just stop turning when you get the empty chamber under the hammer.
MG
I do the ol' load one, skip one, and I seem to be the only one on the parade ground in step, but I like doing it the old fashioned way and there is nothing like chucking those big ol' 45s into the cylinder. I check all my ammo before leaving for the rangeand high primers are one of the things I check.