Howdy, Pard,
IMHO, I'd opt for the Ruger Redhawk or Super Redhawk in .44 Magnum. I know there are folks who tell you that you can load a .45 LC up to equal the .44 Magnum (in velocity, but NOT in pressures!!!), but the advantage to the .44 Magnum case is that it is thicker and smaller in diameter than the .45 LC, which gives you a bit more strength margin. In addition, I'd bet you can find hunting loads in factory ammo in more places with the .44 Magnum. In addition, you can shoot .44 Russian, .44 Colt's Modern, .44 Special and .44 Magnum, which gives you a heckofalot of ammo choices.
On the other hand, the Ruger is available in .454 Casull, which gives you six (yes, six) shots, and the option of shooting .45 LC, .45 Schofield, or even .45 Cowboy Special. I suspect you'll shoot a LOT more of the lighter loads than the heavier ones. And I'm NOT a lover of full-bore .454 loads in a double action gripframe revolver! They are stout enough in a Freedom Arms M87!
The Ruger's are hellferstout!
If I were you, I'd try to find somebody who will let you shoot whatever gun you think you want.