Howdy
I don't own any rifles chambered for 45 Colt, but I own plenty of revolvers that are chambered for it. When I started reloading 45 Colt a few years ago, my manuals listed 8 grains as the MAX for Unique in a 45 Colt under a 250 grain bullet. Consequently, I throttled back a little bit from the max to 7.5 grains of Unique.
Having seen older manuals than mine, I believe the 8 grain max is less than earlier manuals listed for the same load. However, I stick with the information that is published in the manuals I own.
Personally, I would not put in any more than 8 grains of Unique into that load. Shooting it out of a '92 would be one thing, the '92 design is like a bank vault compared to a toggle link gun. Don't forget, the toggle link guns are heavy. Probably a good pound heavier than a '92. Shooting relatively hot loads out of them may be deceptive, recoil wise.
I do not know at what point you will start stretching the frame with a brass framed toggle link gun like a '66, but there is a point at which it will happen. Mike Venturino writes about a brass framed Henry that was stretched and ruined by just a few rounds of 'high powered' loads in his book Shooting Lever Guns of the Old West. Granted, he did not specify the load, but go too high in a brass framed toggle link gun and you are asking for trouble. Why push it? If you want to shoot hot 45 Colt loads, buy a '92.
Just This Cowboy's Humble Opinion.