With the grips as shown - there should be a short pin installed at the bottom of the grip strap.
That'll ensure that the grips are aligned, while the grip screw ensures that they're held tightly.
The grips shown are not one-piece grips.
True one-piece grips would be smooth on both sides, and are fitted by using a glued-in spacer of the same material (or wood) that's been exactly cut and sanded to fit the inside rear of the backstrap, before being epoxied to both sides.
Fitting grips properly can take some time - and if done right, there's no space between the frame/backstrap, and the frame and grip flow together.
Colt fitted them by sanding them to the straps before final finishing, but since most grips today are aftermarket - extra care needs to be taken to avoid scratching the finished metal surfaces.
Good Luck!
Vaya,
Scouts Out!